Endocrine Abstracts

Objectives: High-fructose corn syrup (HFSC) is used as an artificial sweetener. However, there is limited information about the metabolic effects. Fructose is implicated in the etiology of nonalcoholic fatty liver disease(NAFLD). Unfortunately, no therapy for NAFLD currently exists. The aim of this study was to investigate the hepatic lesion induced by chronic HFCS consumption and the protective effects of alpha-lipoic acid (ALA) on hepatic pathology.Met...

Propylthiouracil (PTU), used to treat thyroid dysfunctions such as Graves’ disease, rarely induces lupus-like syndrome. A 52-year-old woman developed dermatological findings of systemic lupus erythematosus with malar rash, photosensitivity and discoid lupus erythematosus-like lesions, after 3 weeks of exposure to the drug. ANA and anti-dsDNA were positive. Skin biopsy of face revealed vacuolar changes in basal layer and lymphoid infiltration in perivascular region of derm...

Objectives: The European Network for the Investigation of Gender Incongruence (ENIGI) is a multicenter prospective cohort study. All participants receive a standardized gender affirming treatment protocol including regular follow-up visits. The current study compared the changes in androgens upon starting hormone treatment and during follow-up in transgender women (TW) with or without gonadectomy by investigating serum total (TT), calculated free testosterone (cFT), DHEA, DHEA...

People with diabetes are at increased risk for developing tuberculosis than non-diabetics. We presented a patient with recurrent diabetic ketoacidosis who was later diagnosed with pulmonary tuberculosis.Case: A 22 year old male with type 1 diabetes for nine years was admitted to the emergency service due to nausea and vomiting. Detecting high anion gap with metabolic acidosis in his blood gas), and ketones in urine analysis,the patient was hospitalized f...

Background: Exercise training has become an important adjunct therapy for both the prevention and management of type II diabetes mellitus. Interest in telemedicine is increasing as a potentially innovative and sustainable intervention approach to diabetes management. Telemedicine can facilitate the achievement of individualized treatment goals by training patients to manage their own disease.Objective: To evaluate the effect of telemedicine on exercise c...

Steroid hormones are important regulators of many physiological processes. The steroid precursor pregnenolone is converted through several enzymatic steps into all types of steroids, including the stress hormone cortisol. Mitochondrial steroidogenic cytochrome P450 (CYP) enzymes crucially relying on electron transfer from the redox partner ferredoxin (FDX1) are involved in key steps of the cortisol biosynthesis pathway.Cortisol is well-known regulator of...

Background/purpose: The combination of DM and HT accelerates vascular complications and increases the risk of mortality and morbidity. Hypertension is seen in half of diabetic patients. HT can be detected in approximately 40% of newly diagnosed diabetic patients. DM frequency increased 2.5 times in hypertensive patients. The association of HT and DM is due to the common mechanism responsible for the pathogenesis of both diseases. There is a limited number of studies investigat...

Objective: Nonalcoholic steatohepatitis (NASH) is a metabolic disease characterized by liver steatosis. There is a correlation between liver steatosis and metabolic hormone dysregulation. Subfatin and asprosin are two important metabolic components of adipose tissue and play a role in carbohydrate metabolism, insulin resistance, and glucose regulation. Therefore, the primary aims of this study were to determine how serum and salivary subfatin and asprosin levels change simulta...

ObjectivesThe European Network for Investigation of Gender Incongruence (ENIGI) is a multicenter prospective cohort study. All participants receive a standardized gender affirming treatment (GAHT) protocol including regular follow-up. The current study compared changes in androgens upon starting GAHT and during follow-up in transgender women (TW) with or without gonadectomy by investigating serum total testosterone (TT), calculated free testosterone (cFT...

Introduction: Parathyroid hormone (PTH) is a peptide-based hormone that controls the level of ionized calcium in blood and extracellular fluids. Hemostasis is regulated by the balance between natural stimulants and inhibitors on platelet functions. Disruption of the balance between inhibitor and stimulants leads to thrombosis or bleeding. There are studies on the association of hyperparathyroidism with thrombotic disease. Thromboelastography is a method of evaluating the whole...